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KMID : 0378019780210120112
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New Medical Journal
1978 Volume.21 No. 12 p.112 ~ p.116
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A study of clinical course of "minimal change" glomerulonephritis
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Abstract
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The Nephrotic syndrome is commoner in children than in adults, and because the "minimal change" lesion is by far the commonest underlying pathology in children.
In adult life, the nephrotic syndrome is rather rare and only 20 to 30 percent of nephrotic adults can be expected to show a "minimal change" lesion.
We describe 17 patients who developed a nephrotic syndrome after age of 15 years, and who showed a "minimal change" pattern in their renal biopsies.
Among the 17 patients with "minimal change" lesions, 2 had spontaneous complete remission, 2 had complete remission with corticosteroids therapy and 1 died of severe cellulitis. 9 among the 12 surviving patients sustained remissions after drug with-drawal, and their renal function remains rather excellent. We report here our experience with "minimal change" glomerulonephritis in adult population and we have found that histologically seperating these patients into groups with "minimal change" lesions helps to predict their response to treatment as we as their subsequent clinical course.
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